What It Is

Penile neurotoxin therapy (also known as “Penile Botox”) is an advanced, injectable treatment that enhances both erectile function and flaccid aesthetics by improving blood flow through the erectile chambers. This non-surgical approach uses precise, ultrasound-guided injections of botulinum toxin—including Botox® and Xeomin®—to relax cavernosal smooth muscle, allowing for better arterial inflow and more consistent performance.

At Miami Men’s, this therapy is delivered using an exclusive, evidence-based protocol developed by Dr. Adam De Fazio, incorporating diagnostic imaging, tailored dosing, and integration with complementary performance-enhancing therapies.

Who It’s For

Penile neurotoxin therapy is ideal for men who:

Have erectile dysfunction that is only partially responsive—or unresponsive—to PDE5 inhibitors or ICI therapy
Want to improve erection quality, firmness, or consistency
Desire a long-acting, low-maintenance, and spontaneous approach to erectile performance
Seek enhanced flaccid fullness and resting girth
Are interested in elevating performance, not just treating dysfunction

Miami penile botox therapy model smiling

How It Works

Injected directly into the corpora cavernosa under ultrasound guidance, botulinum toxin relaxes the smooth muscle tissue responsible for regulating penile blood flow. This leads to:

Increased arterial inflow
Improved rigidity and responsiveness
Sustained enhancements in vascular function, even at rest

This is not just cosmetic injection. It is a clinically optimized, performance-directed treatment backed by real-world data and published studies. At Miami Men’s, we tailor the approach to each patient’s vascular profile, using real-time Doppler analysis to guide dosing and injection points.

What to Expect

Procedure Duration: 20–30 minutes, performed in-office
Comfort Protocol: We offer local penile nerve blocks, topical anesthetic, and nitrous oxide to ensure optimal comfort
Onset of Action: Within 1–2 weeks
Peak Effect: Typically observed by week 3
Duration of Results: 4–6 months
Repeat Treatments: Improved efficacy with subsequent cycles — response rates can reach 95% by the fourth injection
Downtime: None — patients return to work and normal activities the same day

Benefits

Enhanced erection quality, rigidity, and durability
Increased flaccid girth and fullness — improved appearance and confidence even outside sexual activity
Improved penile blood flow, confirmed via Doppler ultrasound
More consistent response to PDE5 inhibitors and ICI therapy
Fast-acting and long-lasting — peak performance without daily medications or injections
Minimal side effects — typically limited to brief, localized injection-site discomfort
Discreet, in-office procedure with no visible markers or scarring

How Is This Different from ED Medications like Tadalafil, Sildenafil, or Trimix?

Penile neurotoxin therapy represents a modern, elevated approach to erectile performance—designed for men who expect more than short-lived pills or injection-based fixes.

In the 1980s and ’90s, the inflatable penile prosthesis (IPP)—the infamous bombita—was the gold standard for severe ED. The 2000s brought oral medications like sildenafil (Viagra) and tadalafil (Cialis) into widespread use, helping millions but requiring careful timing and offering only temporary effects.

Today, penile neurotoxin moves beyond on-demand solutions to offer long-acting, spontaneous function. Instead of chemically triggering erections at the moment of activity, this therapy reconditions the penis to function better at baseline by enhancing flow, tone, and responsiveness without the need to plan ahead.

Treatment	Mechanism	Duration	Spontaneity	Dosing Frequency
Sildenafil (Viagra)	PDE5 inhibitor	4–6 hours	Low – timed	Per use
Tadalafil (Cialis)	PDE5 inhibitor (longer half-life)	Up to 36 hours	Moderate	Per use or daily
Trimix	Direct injection (vasodilation)	~2-3 hours	Low – prep required	Per use
Penile Neurotoxin	Smooth muscle relaxation + basal flow enhancement	4–6 months	High – no prep	2–3x/year

This treatment is not just for men with dysfunction — it’s for those seeking to optimize. It’s for men who want effortless, confident spontaneity without sacrificing efficacy.

Penile Botox Therapy Frequently Asked Questions

Is this the same as cosmetic Botox?

No. While Botox® and Xeomin® are used, the goal here is purely functional. The injections are performed into the erectile chambers (not the skin), targeting vascular tissue rather than muscle.

Is penile neurotoxin safe?

Yes. Multiple high-quality studies confirm a strong safety profile with no systemic effects. The most common side effect is minor, short-lived discomfort at the injection site.

Can I still take Viagra or Cialis if needed?

Yes. In fact, botulinum toxin often enhances the effect of PDE5 inhibitors, allowing some men to use lower doses or eliminate the need altogether.

Will it work if I’ve already failed medications or injections?

Often, yes. Studies show substantial improvement in men who were previously non-responders to both PDE5-Is and Trimix.

How often will I need it?

Most men repeat the treatment every 4–6 months. Response rates increase with each treatment cycle.

Why Miami Men’s

Miami Men’s is among the first clinics in the U.S. to integrate penile neurotoxin into a structured sexual optimization program. Our exclusive protocol, developed by Dr. Adam De Fazio, combines high-resolution imaging, dosing precision, and a full-spectrum understanding of erectile hemodynamics.

This isn’t cosmetic. This is performance medicine.

Book Your Private Consultation

Experience what’s next in men’s sexual health. Request a consultation with Miami Men’s and explore how Penile Neurotoxin Therapy can redefine your performance.

COSMETIC SURGERY - SEXUAL HEALTH - WELLNESS

Enhanced confidence is closer than you think.

135 San Lorenzo Avenue, Suite 760, Coral Gables, FL 33146

Penile Botox Therapy for Erectile Performance & Aestheticsin Miami